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 Lions mane benefits 

A double‐blind, parallel‐group, placebo‐controlled trial was performed on 50‐ to 80‐year‐old Japanese men and women diagnosed with mild cognitive impairment in order to examine the efficacy of oral administration of Yamabushitake/Lions mane  (Hericium erinaceus), an edible mushroom, for improving cognitive impairment, using a cognitive function scale based on the Revised Hasegawa Dementia Scale (HDS‐R). After 2 weeks of preliminary examination, 30 subjects were randomized into two 15‐person groups, one of which was given Yamabushitake and the other given a placebo. The subjects of the Lions mane group took four 250 mg tablets containing 96% of Lions mane dry powder three times a day for 16 weeks. After termination of the intake, the subjects were observed for the next 4 weeks. At weeks 8, 12 and 16 of the trial, the Lions mane group showed significantly increased scores on the cognitive function scale compared with the placebo group. The Lions mane group's scores increased with the duration of intake, but at week 4 after the termination of the 16 weeks intake, the scores decreased significantly. Laboratory tests showed no adverse effect of Lions mane. The results obtained in this study suggest that Lions mane is effective in improving mild cognitive impairment.  

https://scholar.google.com/scholar_lookup?journal=Phytotherapy+Research&title=Improving+effects+of+the+mushroom+Yamabushitake+(Hericium+erinaceus)+on+mild+cognitive+impairment:+a+double-blind+placebo-controlled+clinical+trial&author=K.+Mori&author=S.+Inatomi&author=K.+Ouchi&author=Y.+Azumi&author=T.+Tuchida&volume=23&issue=3&publication_year=2009&pages=367-372&pmid=18844328&doi=10.1002/ptr.2634&#d=gs_qabs&t=1673028502540&u=%23p%3DmVYCZJzwfUoJ

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